If you’d like to use CBD oil to help ease your arthritis pain, you may be wondering how much to administer or apply. However, when talking about proper CBD dosing, it’s important to first understand bioavailability.
Bioavailability is defined as the “amount of a substance that becomes available (reaches the target organ or system circulation) to an organism’s body for bioactivity when introduced through ingestion, inhalation, injection, or skin contact.” In short, it is how much of the substance your body can effectively use based on the type and route taken.
In the case of CBD oil specifically, Medscape shares that while intranasal administration of CBD has a bioavailability of 34 to 46 percent and CBD vaporization has 40 percent bioavailability, “oral CBD is thought to be as low as 6 percent, owing to significant first pass-metabolism.”
First-Pass Metabolism and CBD
An article published in the journal Nurse Prescribing explains that first-pass metabolism occurs in the gut or the liver and is when some of the drug is destroyed before it is able to be circulated around the body. Thus, based on the research above, taking CBD oil in pill form may mean that your body only receives as little as 6 percent of the CBD.
Another option is to take CBD oil topically, either alone or as part of a lotion or cream. Research published in the European Journal of Pain studied the effectiveness of this approach and found that “topical CBD application has therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.”
Proper CBD Dosing
Because CBD is so new, Medscape recommends that users “start low, go slow.” This enables you to see how well your body responds without giving it more than the necessary amount.
Plus, there are no government regulations regarding the manufacture and sale of CBD, so you never know if you’re getting the amount actually listed on the label. This makes erring on the side of caution even more important.